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Description
GLP-1 receptors in the ventral tegmental area sit on GABAergic neurons rather than on dopamine neurons, so the agonist raises inhibitory tone onto dopamine cells rather than acting on them directly

Long-term adherence to oral therapy showed that patients who maintained consistent dosing schedules achieved sustained weight loss over 12-24 months

Flint et al

Can I take it orally

Tirzepatide trials (SURPASS series) showed similar safety profiles for mood-related adverse events

Continue taking your medication as directed unless advised otherwise by your healthcare team
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