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They work by inhibiting glucagon secretion, delaying gastric emptying, and suppressing appetite, which helps regulate blood sugar levels and promote weight loss.However, concerns have been raised in recent years over whether these medications reduce weight mainly via muscle mass loss, which could lead to physical frailty or sarcopenia.Led by assistant professor

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Obesity has escalated into a global epidemic, with over 1 billion individuals affected worldwide, including nearly 880 million adults and 159 million children and adolescents aged 519 years (World Obesity Federation)