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The study authors noted that 72 percent to 82 percent of people with PsA have overweight or obesity

In the 24-week, placebo-controlled factorial study of initial therapy with JANUVIA in combination with metformin, the incidence of hypoglycemia was 0.6% in patients given placebo, 0.6% in patients given JANUVIA alone, 0.8% in patients given metformin alone, and 1.6% in patients given JANUVIA in combination with metformin

You have to have a couple of replicated studies

COWS says moderate withdrawal

On the flip side, absorption from the thigh can be slightly slower compared to the abdomen, and its important to avoid injecting into muscle tissue to prevent soreness

Patients should seek help immediately about any side effects that are severe or do not go away