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Over the next few years, we will need to monitor how the healthcare system will tackle these issues without the benefit of commercial managed care oversight.

In the three studies, from a mean baseline body weight of 75.3 kg, 73.3 kg, and 76.6 kg, respectively, after randomization there were corresponding mean reductions of 0.8 kg, 1.6 kg, and 1.3 kg (60 mcg TID) and 0.8 kg (60 mcg QID) in the SYMLIN treatment group compared to mean increases of +0.8 kg, +0.4 kg, and +0.7 kg in the placebo treatment group

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Sundelin et al., 2017

These specialized regions detect circulating GLP-1 and GLP-1RAs and relay signals to the hypothalamus, further influencing appetite and body weight regulation