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Previous presentation: These data were presented in part as a poster at the Annual Meeting of the Endocrine Society

When bile acids bind to TGR5 in the smooth muscle cells of the gallbladder, cAMP production increases, leading to muscle relaxation

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NICE guidance on suspected cancer recognition and referral (NG12) provides thresholds for urgent investigation of potential pancreatic cancer, including immediate referral for obstructive jaundice, and urgent direct-access CT scanning (within 2 weeks) for people aged 60 and over with weight loss and specific symptoms