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Worsening markers at any point should prompt reconsideration of the current approach

The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes
The FDA approval of the first oral GLP-1 for weight loss in December 2025-Novo Nordisk's once-daily semaglutide pill-represents a watershed moment for the category [3]

Diabetologia 66(10):17801795

doi: 10.1007/s12020-014-0386-8
