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Oral trauma Hormonal changes related to the menstrual cycle Anxiety or stress Smoking cessation Heredity Drugs (including anti-inflammatory drugs, such as ibuprofen [Motrin, Advil], and beta-blockers, such as atenolol [Tenormin]) Food allergies or sensitivities (chocolate, tomatoes, nuts, and acidic foods such as pineapple, and preservatives such as benzoic acid and cinnamaldehyde) Toothpastes containing sodium lauryl sulfate Deficiencies of iron, folic acid, or vitamin B12 (although supplementation with iron or vitamins has not been shown to increase the likelihood of ulcer resolution) Some studies have suggested an association with Helicobacter pylori , the same bacteria that cause peptic ulcers