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The role of GLP-1 is pretty simple: It tells your brain, Hey, were full. It helps manage blood sugar after meals

Patients should note the date when a pen is first removed from the fridge or when refrigeration is interrupted

The fallback is a brand-name prescription, which is unaffected because it was never compounded

Although investigations in animals are scarce, studies among humans have suggested that GLP-1 RAs directly mitigate the development of coronary atherosclerosis through several mechanisms (Table 1)

However, we also have a constant, low level of circulating GLP-1 even when fasting.[ref][ref] This directly ties into the gut microbiome

If you haven't lost at least 5% of your body weight by week 16, your clinician will reassess and discuss alternative approaches