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Human Genetics Data in Favor of Both Agonism and Antagonism There is increasing reliance on human genetics data to help identify new drug targets

3 Although several factors contributed to this rise in interest, two key developments have been particularly important: Celebrity endorsement: A number of high-profile celebrities, such as Elon Musk, have publicly credited GLP-1RA drugs with their transformative weight loss, leading to a spike in public interest in using the drugs for weight loss

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These studies showed that Januvia significantly lowers A1C levels when used alone or as add-on therapy with medications such as metformin, sulfonylureas, or insulin

Eventually, Wegovy launched as a weight-loss-indicated variation of Ozempic, spurring a slight acceleration in the number of written GLP-1 prescriptions (3% compound monthly growth grate, June 2021 to May 2022)

Estimated glomerular filtration rate, albuminuria, and adverse outcomes: an individual-participant data meta-analysis