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Brain uptake pharmacokinetics of incretin receptor agonists showing promise as Alzheimers and Parkinsons disease therapeutics [published correction appears in biochem pharmacol

The truncated metabolite GLP-2 (333) interacts with the GLP-2 receptor as a partial agonist

Peptides (prepared as 5 solution in HBSS and 20 mM HEPES, pH 7.4) were added at time=10 s and changes in fluorescence were monitored over a period of 250 s following excitation at a wavelength of 488 nm and detection at 510560 nm

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