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Furthermore, SGLT-2i have been linked to elevated SCFA levels in the colon, specifically butyrate and acetate, which are known to affect insulin sensitivity, glucose homeostasis, and appetite control and protect from kidney and cardiovascular disease [14, 35]

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Both drug classes have been shown to confer clinical benefits such as glycaemic control, body mass reduction, and improved systolic blood pressure and lipid profiles, which may collectively contribute to their cardiorenal protective effect.32 However, these drug classes use different mechanisms to achieve these effects

Since its discovery in 1984 by Svetlana Mosjov, GLP-1 and its analogs (such as semaglutide, liraglutide, and dulaglutide) have rapidly become cornerstone treatments for type 2 diabetes mellitus (T2DM) and obesity

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