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The mean HbA1c level decreased by 1.6% (17.5 mmol/mol) and 1.5% (15.9 mmol/mol) in the 2.4 and 1.0 mg semaglutide groups, respectively, and by 0.4% (4.1 mmol/mol) in the placebo group

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Keywords: body composition, fat-free mass, glp-1 receptor agonists, lean mass, low testosterone, obesity pharmacotherapy, sarcopenia, skeletal muscle, testosterone replacement therapy Introduction and background Background Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have emerged as highly effective pharmacologic therapies for obesity and type 2 diabetes mellitus, producing substantial and sustained weight loss while improving cardiometabolic outcomes

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14-15 Long-term changes in diet and activity are essential for maintaining weight loss and preventing weight regain after stopping the medication

We were specifically interested in the hypothesis that variation in the circulating estrogen level is a determinant of responsiveness to these drugs