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[2] [3] Based on the known class effects of GLP-1 and GIP receptor agonists, the following additional cautions are relevant, even where retatrutide-specific data are still emerging: Acute pancreatitis : Participants should be advised to seek urgent medical attention if they develop severe, persistent abdominal pain particularly pain radiating to the back accompanied by vomiting, as this may indicate pancreatitis

The appetite-suppressing effects of GLP-1s, along with common side effects such as nausea, vomiting, and diarrhea, may promote excessive dietary restrictiona serious concern in eating disorders

Muciniphila and Metabolic Effects

Patients with multiple comorbidities, especially those with limited treatment options, are significantly more likely to initiate GLP1 therapy