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JAMA Neurol 2019;76:420429.ArticlePubMedPMC 114

PMID 37952131 Jastreboff AM et al

These digital interventions, apps, wearables or web platforms using ACT, help people keep weight off after initial losses

Upon activation, AMPK signals through its downstream substrates to restore normal energy levels by stimulating processes that generate ATP (such as fatty acid [FA] oxidation) and inhibiting those that use ATP (such as triglyceride and protein synthesis)

Track your blood glucose if you have diabetes, watch for signs of hypoglycemia if you're taking other glucose-lowering medications, and report any severe or concerning symptoms to your healthcare provider

This approach initially appears counterintuitive