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Subsequently, more sophisticated studies confirmed these findings using unbiased approaches including single-cell sequencing to define cell-specific antifibrotic effects of GLP-1 analogs in the kidney (63)

Some patients also explore alternative medications within the GLP-1 class

95% CI 1.6, 0.39), phentermine/topiramate (WMD: 0.7

Although past meta-analyses reported substantial reductions in MACE with DPP-4 inhibitors [23], their conclusions were based on studies with small sample sizes and limited numbers of cardiovascular events, which have not been confirmed by the four CVOTs specifically designed to assess the CV safety of DPP-4 inhibitors