glp 1 action Mechanism of of GLP-1 [25] Mechanisms of action of GLP-1RA.

Though these drugs have been deemed effective in treating T2DM, the Food and Drug Administration (FDA) and some members of the scientific community have questioned the safety of these therapeutics relative to important cardiovascular endpoints

Significance statement ![Figure][1] ### Competing Interest Statement The authors have declared no competing interest

Retention of glucagon function is required to achieve such an advantage over GLP-1 monotherapy

Tirzepatide, a dual GLP-1/GIP receptor agonist has been approved for glycaemic control in type 2 diabetes as well as for obesity management leading in up to 22.5% WL in phase 3 obesity trials

Learn how GLP-1 works, plus GLP-1 promoting foods that may naturally support this powerful weight loss hormone, with or without medication.

Looking for alternatives to Ozempic or Wegovy