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46 Drug-Drug Interactions: Saxagliptin is a strong CYP3A4 inhibitor, so its labeling recommends limiting saxagliptin to 2.5 mg daily in patients taking other strong CYP3A4 inhibitors, such as ketoconazole, based on the risk of increased saxagliptin levels

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For some, these symptoms become unbearable, making it difficult to continue with treatment

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