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The biggest difference in the semaglutide vs tirzepatide discussion is that Semaglutide works only on GLP-1 receptors, while Tirzepatide activates both GLP-1 and GIP receptors
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Clinical trials show tirzepatide produces 2022% weight loss at the highest dose, compared to 1517% for semaglutide in head-to-head comparisons

Overall, cardiovascular safety has been well-demonstrated in clinical trials
