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Saxenda contains the active ingredient liraglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist

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The mechanisms by which GLP-1 RAs induce weight loss are multifaceted and are linked to GLP-1R activation in both central and peripheral enteric neurons, slowing gastric emptying and intestinal transit, as well as suppressing appetite at the hypothalamus level, collectively influencing a mechanism known as the ileal brake

Patients seeking weight management support in the UK should discuss licensed options such as semaglutide (Wegovy) or tirzepatide (Mounjaro) with their GP or specialist obesity service

2a and Supplementary Table 4)

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