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Thus, GLP-1/FGF21 fusions have the potential, at least in rodents, to provide greater improvements in dyslipidemia than GLP-1R agonists and have the potential to drive greater body weight loss through the energy expenditure mechanism not evident with GLP-1 mono-therapy

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Medically reviewed by Heather Franco, APRN, FNP-C July 2026

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Given the known action of GLP1RAs in the brain, studies in rodents have examined the effects of GLP1RA exposure on the fetal and neonatal brain

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