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The AUC of metformin was increased by 32% (90% confidence interval 1.231.43) by oral semaglutide coadministration versus metformin alone, whereas the Cmax was unaffected

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Compared to baseline, DIO mice assumed phylogenetically similar gut bacterial compositional changes following liraglutide and GUB09-145 treatment, characterized by discrete shifts in low-abundant species and related bacterial metabolic pathways

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