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on the contrary, it is dispersed heterogeneously, mainly as single cells, along the epithelium of the GI tract, from the stomach to the rectum with a defined cephalocaudal, crypt-to-villus in the small intestine and crypt-to-surface distribution in the colon ( Despite representing just 1% of the adult gut epithelium, in the last decade it has become clear that the EECs constitute the largest endocrine organ in mammalia ( Collectively, the EECs are responsible for the production of more than 30 different hormones that help to orchestrate the fate of the intermediary metabolism

Scheme 26

Obesity, primarily associated with the increased burden of non-communicable diseases (NCDs), has been linked to healthcare costs approximately 30% higher than those of individuals with normal body weight [9]

5, 6 This indicates that it is the size of reduction in free leptin, from before the weight loss to 52 weeks after weight loss, rather than the absolute post-weight loss values that control food-seeking behavior

Fatigue : About 7% of individuals report feeling tired or weak, often due to reduced caloric intake

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