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Concurrently, GLP-1 stimulates the translocation of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) into the nucleus via the PKA/ERK signaling pathway, where Nrf2 induces transcription of genes for SOD, GPx, catalase, thioredoxin, and other antioxidant enzymes, further enhancing the cellular antioxidant defense system

Protecting yourself while using GLP-1 medications Not everyone reading this guide has been injured

Tirzepatide is also under investigation for the reduction of morbidity and mortality in people with obesity and overweight without diabetes (NCT05556512)

Scientific References The hypothalamus as the central regulator of energy balance and its impact on current and future obesity treatments

Addressing Root Causes To maintain your weight loss over time, youll need to continue making healthy lifestyle choices, such as addressing any underlying issues contributing to your weight gain, including: Hormonal imbalances Dietary changes Regular exercise Other root causes What Are the Risks of Taking GLP-1s Long-Term