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An alternative that achieves similar weight loss but with fewer gastrointestinal side effects or different tolerability characteristics may actually be preferable, even if the mechanism differs

[77] discovered that tirzepatide therapy drastically reduced the expression of the apoptotic marker BAX/Bcl2 ratio while up regulating markers such as MAP2, GAP-43, and AGBL4, all of which are important for neuronal plasticity and differentiation

doi: 10.1016/j.tcm.2021.12.008

Therefore, to reduce the potential heterogeneity and bias, the inclusion criteria were strictly set as: (1) RCTs with participants free from documented hearing loss at baseline

critically revised the manuscript

Start low and go slow with dosing