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The physiological effects of GIP, GLP-1, and GLP-1RAs on bone metabolism have not yet been determined, and studies are needed to examine the effects of gut hormone on human osteoblast differentiation and osteoclast activity, including their potential interactions with Wnt and NF-kB signaling
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Insulin Resistance Development: The menopausal transition frequently precipitates declining insulin sensitivity in women, creating challenges with blood sugar regulation that manifest as increased cravings for carbohydrates, energy crashes between meals, and difficulty mobilizing stored fat for energy utilization during weight loss attempts

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