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The participants were all classified as either overweight or having obesity, with an average baseline weight of 248.5 pounds

Details of the National Institutes of Health-funded study were published this week in a Nature paper titled A brain reward circuit inhibited by next-generation weight-loss drugs in mice. In it, the team reported that they investigated the small-molecule GLP-1s including Eli Lillys recently approved drug orforglipron, also known by the brand name Foundayo, as well as danuglipron, an oral GLP-1 that was being developed by Pfizer until the company decided to discontinue its development in 2025

After weekly subcutaneous injections, diffusion and microsphere rupture released Exenatide microspheres into the bloodstream over 68 weeks, allowing the medicine to reach a stable plasma concentration