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Description
Gastrointestinal side effects are the most commonly reported and include: Nausea affects a significant proportion of patients, particularly during dose escalation Diarrhoea may be mild to moderate and usually improves with time Vomiting less common than nausea but can occur, especially at higher doses Constipation some patients experience reduced bowel movements Abdominal pain or discomfort typically mild but should be monitored Reduced appetite contributes to weight loss but may be excessive in some individuals These gastrointestinal symptoms are generally most pronounced when initiating treatment or increasing the dose
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Thus, GLP-1-based therapy is nowadays widely used in the treatment of type 2 diabetes, especially in obese subjects
