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Other clinically relevant GI complications include cholelithiasis, which occurred about 50 % more often, and gastroesophageal reflux disease (GERD), which occurred roughly twice as often, in patients receiving GLP-1 therapies compared with placebo [33]

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The main differences are faster absorption, potentially more intense temporary side effects, and increased pain at the injection site

doi: 10.1111/j.1442-9993.2001.01070.pp.x 34 MagneFGottelandMGauthierLZazuetaAPesoaSNavarretePet al

If youre interested in learning whether retatrutide may be appropriate for your health goals, the first step is to schedule a consultation with a qualified healthcare provider

How It Helps Adults With Obesity In clinical studies, orforglipron produced dose-dependent reductions in body weight, with the highest doses delivering the strongest effects