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These effects have made them highly effective and, in many cases, revolutionary for managing metabolic health

Psychiatry 72 , 354360 (2012)

Gastrointestinal symptoms, such as nausea and bloating, are usually temporary and tend to resolve as treatment continues, especially once a stable dose is reached

They help reduce hunger, increase fullness, and improve metabolic regulation, which can make it easier for patients to sustain a calorie deficit over time

The GLP-1R are expressed in tissues other than pancreatic islets 24 , as in hepatocytes, but studies suggest that certain actions of GLP-1 in hepatic glucose metabolism occur through mechanisms that are independent of GLP-1R, and no alternative route seems to have been fully elucidated 25

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