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In a clinical trial, people on tirzepatide experienced an average of 15% weight loss on 5 mg, 19% on 10 mg, and 21% on 15 mg

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Chronic infusion of acyl-GIP into the lateral ventricle of DIO mice, however, robustly decreases body weight and food intake at doses of as little as 0.02 nmol/day, and these effects vanish in mice with Nestin Cre-mediated neuronal loss of Gipr [795]