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Starting at higher body weight If you are beginning your GLP-1 protocol at a higher body weight, you likely have ample subcutaneous tissue at all three injection sites

Semaglutide's main advantages are its proven cardiovascular benefit and lower injection site reaction rate

yet these agents may favor an increase of lean mass and mimic an energy deprivation state with increased ketogenesis (i.e., BHB) through increased circulating GH levels ( Figure 1 )

Dehydration can affect kidney function, so keeping an eye on creatinine and eGFR levels is a good idea, especially if you have nausea or vomiting

"With newer GLP-1based therapies now emerging, the field has an opportunity to test whether different drugs in this class have distinct effects on aging biology and to identify which patients may benefit most," said Corley

That is the elegance of the semaglutide approach