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Managing Expectations: Timeline and Real-World Results Weight loss on semaglutide follows a predictable but individualized timeline: most patients see modest results in weeks 1-4 (1-3 lbs), accelerating between weeks 5-12 as their dose reaches therapeutic levels

Eur J Gastroenterol Hepatol 2000

However, higher doses also increase the risk of gastrointestinal side effects during the initial weeks, so most treatment protocols begin at 0.25 mg and increase gradually over 16 to 20 weeks