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Table of Contents Regenerons Phase 2 COURAGE Trial: A New Strategy for Muscle-Sparing Weight Loss The Challenge What the COURAGE Trial Tested Population : Adults with obesity (BMI 30 kg/m) Treatments (Phase 1, Weeks 026): Semaglutide alone

Unlike Mounjaro, however, Zepbound is FDA-approved to support weight management for people living with obesity or overweight who have at least one weight-related condition, such as type 2 diabetes, high cholesterol, or hypertension (high blood pressure)

8 Analysts project that once Chinese and Indian generics enter the market in 2026, at least one in three people living with obesity globally will reside in a country where semaglutide is available off-patent

Klausen MK, Jensen ME, Mller M, Le Dous N, Jensen A-M, Zeeman VA, et al

10.1038/srep26859 108

Serious Considerations Pancreatitis: GLP-1 medications carry warnings about potential pancreatitis risk