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Authors contributions Substantive scientific and intellectual contributions to the study: Conception and design: Jos A

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Effectiveness of Oral and Subcutaneous Semaglutide Statistically significant improvements from baseline were seen for both formulations in HbA 1c (19.3 18.4 mmol/mol [ 1.77 1.68%] and 20.8 15.4 mmol/mol [ 1.90 1.41%] for oral and subcutaneous respectively), body weight ( 9.0 10.2 kg and 7.2 9.4 kg), BMI ( 3.3 3.8 kg/m 2 and 2.5 3.3 kg/m 2 ), and total cholesterol ( 0.24 0.49 mmol/l and 0.38 0.92 mmol/l), (Fig