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Description
It impairs insulin sensitivity, increases cortisol production, and reduces the secretion of growth hormone, which plays a critical role in fat oxidation and muscle preservation during sleep
Despite the lack of extra support for lifestyle modification as part of the SURPASS program, 4069% of patients achieved 10% weight loss with the highest doses of tirzepatide (1015 mg), which ranged from 9.5 kg to 12.9 kg [100]
G protein-coupled receptor (GPR) 120 (free fatty acid receptor [FFAR] 4) and GPR40 (FFAR1), which are known as long-chain fatty acid (LCFA) receptors, are expressed in K cells and involved in GIP secretion in response to fat intake [29, 31, 52-54]
As the concentration of the drug continues to drop over the following weeks, side effects should fully resolve
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10.1056/NEJMoa2032183 [DOI] [PubMed] [Google Scholar] 30
