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Network and Community analysis revealed the involvement of highly conserved class B1 GPCR residues for transmission of information through the GLP-1R TM bundle

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92 The nuclei containing GLP1-R are located in the circumventricular area postrema and median eminence, as well as in the nucleus of the solitary tract (NTS)

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In addition, circulating endogenous MOTS-c levels increase 1.6-fold during exercise, 1.5-fold after exercise, and then return to baseline levels after 4 hours
