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S.BaumbachA.BhmM.et al (2023)

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Extensive clinical trials have shown that GLP-1 receptor agonists can lead to significant, sustained weight loss in people with obesity or overweight, even if they do not have diabetes

The strengths of this trial include its prospective design with a priori defined endpoints, the inclusion of approximately equal percentages of men and women and 41.8% of participants identifying as Hispanic or Latino, the evaluation of liver fat and body composition by MRI and the measurement of several biomarkers to indirectly assess progressive MASLD and suggest potential mechanistic insights

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There are individuals obtaining these drugs via unauthorized avenues, and the FDA has issued warning letters to violators