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Peptides that regulate food intake: glucagon-like peptide 1-(7-36) amide acts at lateral and medial hypothalamic sites to suppress feeding in rats

(2012) GIP-overexpressing mice demonstrate reduced diet-induced obesity and steatosis, and improved glucose homeostasis

see Figure 2 for a graphical display of the product as a volcano plot

GLP-1 receptors in the hypothalamus and brainstem mediate appetite suppression and satiety, contributing to weight loss through reduced caloric intake

Its especially important when weight loss is rapid

Rescue therapy was used in 12% of patients treated with Januvia 100 mg and 27% of patients treated with placebo