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Postprandial glucagon-like peptide-1 secretion is increased during the progression of glucose intolerance and obesity in high-fat/high-sucrose diet-fed rats

Acetate, a histone deacetylase inhibitor, can suppress the activation of the NLRP3 inflammasome and restore the overactive kisspeptin system in rat models (110)

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The oral non-peptide GLP-1 receptor agonist market was dominated by North America in 2025 due to the high prevalence of obesity and diabetes, strong pharmaceutical research capabilities, and widespread adoption of innovative therapeutics

Statistical analysis We characterized the baseline characteristics of the combination and monotherapy groups by reporting frequency distributions (counts and percentages) for categorical variables and descriptive statistics (means and standard deviations [SDs]) for continuous variables