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These early appetite shifts can make it easier to reduce portions and avoid frequent snacking, which may lead to gradual weight loss even at the starter dose

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Incretin mimetic medications known as GLP-1RAs improve glucose management by decreasing stomach emptying, decreasing GCG release, and enhancing insulin secretion and sensitivity [23]

Specifically, that work involves increasing insulin production, limiting the release of glucagon (a hormone that raises blood sugar), and slowing gastric emptying (the process in which food moves from your stomach into the intestines)

This echoes the findings of a 2013 review, which found neither firm evidence in favor of this hypothesis nor evidence strong enough to rule out any such increased risk. Recent research also points to a link between the GLP-1 receptor agonist semaglutide and worsening diabetic retinopathy (DR)