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Investigation of the mechanisms underlying the beneficial metabolic effects of multi-agonist therapies, conducted in PWA mice, as a genuine model for the metabolic alterations of PCOS 36 , revealed a predominant action in terms of suppression of food intake, with negligible effects in terms of energy expenditure, thermogenic function or locomotor activity

Key storage and handling recommendations include: Keep pens in the original carton until use to protect from light Do not store pens in the freezer compartment or near the freezer element in your refrigerator Avoid leaving pens in hot environments such as cars, windowsills, or near radiators Handle the pen carefully to minimise excessive agitation that might increase air bubble formation Check the expiry date before each use and never use an expired pen If a pen has been stored above 30C or out of the fridge for more than 14 days, do not use it Store pens out of reach of children and pets If you have questions about whether your Trulicity pen has been stored correctly, or if you are unsure whether it is safe to use, contact your community pharmacist or diabetes care team for advice

You can detect it by gently pressing on your injection zonesif you feel small, firm, rubbery bumps under the skin, that is likely lipohypertrophy

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A quantitative synthesis will be applicable if more studies are completed and results are fully published

Mice were single housed 1 week before surgery and metabolic tests started after a recovery period of 3 weeks