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Additionally, alcoholic beverages often contain empty calories and can contribute to weight gain

Collectively, you can see why these are attractive features when targeting glucagon in the corporation of the treatment of diabetes and obesity. Activation of the glucagon receptor with the triple-hormone receptor agonist retatrutide is being investigated in a large phase 3 program that includes 14 trials, among them TRANSCEND-T2D-1 and TRIUMPH-1, and more than 22,000 participants

Participants were randomly assigned to receive retatrutide at varying doses or placebo over 48 weeks

The dosage may be gradually increased over several weeks to minimize side effects

[DOI] [PMC free article] [PubMed] [Google Scholar] 2.Gratzl S., Cartwright B.M.G., Rodriguez P.J., Gilbert K., Do D., Masters N.B., et al