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This led to large dedicated weight-loss trials in people with overweight or obesity, including people without diabetes

Semaglutide was groundbreaking in initial trials

Watching for red flags like persistent upper right abdominal pain, fever, or yellowing skin, and contacting a provider as soon as they appear, is the most reliable way to catch a problem early

According to the CBS News investigation, exposures tracked by Americas Poison Centers increased significantly between late 2025 and early 2026

Pregnancy planning or active pregnancy is another scenario requiring GLP-1 postponement, regardless of thyroid status

It's super lightweight
