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Other companies are close behind with their own oral GLP-1 options, including pills like orforglipron, which has shown promising results in clinical trials

Ozempic is a GLP-1 receptor agonist that stimulates insulin secretion, suppresses glucagon release, and slows gastric emptying to manage type 2 diabetes

Cardiovascular safety may be assessed either before or after authorisation, depending on the indication and the risk profile of the medicine this is determined on a case-by-case basis and is not universally required pre-authorisation, particularly for obesity indications

These are important for appetite suppression and how the body uses food

L., Tan B

Hypersensitivity reactions (rash, pruritus, urticaria) Alongside gastrointestinal issues, another category of side effects that has been observed with retatrutide in the clinical development programme is hypersensitivity reactions