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The trial has enrolled over 13,000 participants and will compare the cardioprotective effects of tirzepatide with the FDA-approved GLP-1 agonist dulaglutide

Two separate cohorts of rats were used in these studies

In this context, the aim of the present document is to summarize, in the form of a narrative literature review, the currently available data on the main mechanisms of action of GIP/GLP-1 co-agonists and the clinical effects of tirzepatide evaluated in various clinical trials

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[57] demonstrated that GLP-1 based agents were associated with a three-fold increased risk of pancreatic enzyme elevation relative to controls, yet did not indicate a significant rise in pancreatitis or pancreatic cancer