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NaB-enhanced hepatic GLP-1R expression via inhibiting HDAC It has been reported that short-chain fatty acids (SCFAs) including NaB are able to regulate the immune response and metabolism through the activation of GPRs, such as GRP43 and GRP109a or through the inhibition of HDAC 27,28

This class of medication has been available for a while, but these drugs really became popular in the past couple years because of their effects on weight management, co-author Serena Jingchuan Guo, MD, PhD, associate professor and AI director at Purdue University College of Pharmacy, told Healio

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EP is principal investigator of a research grant to the Brigham and Womens Hospital from Boehringer Ingelheim, not related to the topic of this work

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But the important questions remain, said DiMarchi