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However, the manufacturing cost advantage creates significant pricing flexibility for Eli Lilly that is not available to manufacturers of peptide GLP-1 agonists

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Similarly, insulin injections failed to reduce circulating glucose levels in Bbs5 / mice (Figure 1M), resulting in a higher area under the curve (Figure 1N)

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Since distribution of GLP-1R in the kidney remains controversial, the renoprotective effects of GLP-1RAs may be partially explained by this mechanism
