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The use of prazosin, an 1-adrenergic receptor blocker, showed that the ability of GLP-1RAs to reduce TNF- in plasma was disrupted, signifying the vital role of 1-adrenergic receptors in the anti-inflammatory action of GLP-1RAs

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Doi: 10.1016/j.cgh.2024.03.013 [DOI] [PubMed] [Google Scholar] 102

In conclusion, while the association between metformin and the incidence of certain cancers remains a subject of debate, metformin exhibits significant protective effects against multiple types of tumors, demonstrating efficacy in inhibiting tumor cell proliferation and progression, reducing cancer risk, and improving cancer-related outcomes [107]