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The MHRA's framework for supplying unlicensed medicinal products ('Specials') and named-patient import routes exist for certain unlicensed medicines, but these mechanisms are generally not applicable to investigational products that are not yet commercially available

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The role of GLP-1 receptor agonists in cardiovascular disease

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These indirect mechanisms allow for central nervous system modulation without requiring substantial penetration of the blood-brain barrier, though direct human data on CNS distribution of long-acting incretin agonists remain limited

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