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Whilst all GLP-1RAs use has increased, the largest change was seen in patients using tirzepatide and semaglutide ([figure 1B][1])

A new biweekly GLP-1 drug called bofanglutide showed strong blood sugar and weight loss results in a Phase 2b trial

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Data from cardiovascular outcomes trials and real-world studies demonstrate consistent benefits of combination therapy across diverse subpopulations, including those with established atherosclerotic cardiovascular disease or chronic kidney disease

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For its cardiovascular benefits, semaglutide is believed to reduce atherosclerosis progression by decreasing gut permeability and inflammation[2]